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Increased fission caused by the upregulation of proteins Fis1 and Drp1 normally promotes mitophagy [309]

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From the payer perspective, the adjusted total cost per patient for the GLP-1RA group was higher than that for the insulin group by US$969, and from the healthcare sector perspective, the adjusted total cost per patient for the GLP-1RA group was lower than that for the insulin group by US$342

This should be considered, not only for the sake of accuracy and to avoid mischaracterization of drugs, but because the existence of ligand bias provides interesting therapeutic opportunities to achieve functional selectivity