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Here's the honest answer: it depends

AirID-CRBN demonstrated biotinylation of IKAROS Family Zinc Finger 1 (IKZF1) and spalt-like transcription factor 4 (SALL4) in a pomalidomide-dependent manner

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1c,d) and was previously suggested as a candidate for a potential activator site, first, because its positive charge might stabilize or bind GSH as GS , and, second, because of its evolutionary conserved position that is equivalent to the GSH-interacting catalytic residue of glutathione transferases 3

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Right, corresponding absolute melting temperature