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Insufficient safety data exist to recommend routine use during pregnancy or lactation

This mechanism may represent a potential driver of excessive endogenous uric acid production

Abbreviations ASGPR: Asialoglycoprotein receptor CAIX: Carbonic anhydrase IX CDT: Chemodynamic therapy CMA: Chaperone-mediated autophagy CI-M6PR: Cation-independent mannose-6-phosphate receptor CMPATAC: Covalent membrane protein aggregate-targeting chimera EGFR: Epidermal growth factor receptor FR: Folate receptor GPC3 : Glypican-3 GSH: Glutathione HER2 : Human epidermal growth factor receptor 2 ICG: Indocyanine green IMTAC: Intelligent modular LYTAC ITGBAC : Integrin 31 bispecific aptamer chimera LMP: Lysosomal membrane permeabilization LYTAC: Lysosome-targeting chimera MedTAC: mRNA-encoded lysosomal targeting chimera MILH : Magnetic intra-lysosomal hyperthermia MILND : Molecularly imprinted lysosomal nanodegrader mNbTAC : Multivalent nanobody-targeting chimera mTORC1: Mechanistic target of rapamycin complex 1 NIR: Near-infrared NLTC : Nanostructured LYTAC PDT: Photodynamic therapy ROS : Reactive oxygen species PROTAC: Proteolysis-targeting chimera PTT : Photothermal therapy SDT : Sonodynamic therapy STAT3: Signal transducer and activator of transcription 3 STING: Stimulator of interferon genes TME: Tumor microenvironment TFEB: Transcription factor EB TfR : Transferrin receptor UPSM : Ultra-pH-sensitive micelles VEGFR2: Vascular endothelial growth factor receptor 2 References Cancer Collaborators GBD

Notably, while simultaneous substitution of these residues negatively impacts ternary complex formation and ubiquitylation of BRD4 BD1 (Extended Data Fig

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Cyanocobalamin clears faster and requires more frequent dosing, so it has largely fallen out of routine use here