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The most common side effects reported in retatrutide results from Phase 2 trials were gastrointestinal in nature, including nausea (affecting up to 45% of participants at higher doses), diarrhea, vomiting, and constipation
Research by Sikiric et al
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This temporal pattern strongly suggests that rapid physiological changes, not gradual fat mass reduction, are driving at least the early component of cardiovascular risk reduction
[1] These outcomes substantially exceeded placebo and represent some of the largest weight reductions reported in a controlled obesity trial
