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Approximately 50% of patients regain significant weight after discontinuing tirzepatide, particularly within the first 12 months post-stop

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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations AgRP, agouti-related protein

Glutathione is a key player in "Phase II" detoxification

Patients whose HbA1c was lower than their pre-GLP-1 level at three months most often had improvement at twelve months as well (55%)

Downregulation of the p53 signaling pathway promotes cellular proliferation and modulates inflammatory responses 71 , while HDAC7 depletion facilitates cell migration, angiogenesis, and extracellular matrix remodeling, collectively contributing to coordinated tissue repair 72