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These medications were designed for long-term, often lifelong, use

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is that GDH overactivity in the brain promotes the formation of astrocytes, resulting in an imbalance between glial and neuronal cells that may lead to seizures and severe developmental defects [5]

The combined treatment demonstrated significantly greater efficacy than standard-dose pregabalin or acetyl-l-carnitine alone, in terms of both pain symptoms measured by improvement on the VAS score (+12.8%) and neurosensory symptoms measured by the DN4 tool (+22%)

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and O.D.) independently screened titles and abstracts for relevance, assessed the full texts for eligibility and extracted relevant data