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These medications are FDA-approved for chronic weight management

Observational studies of people with diabetes [47, 48] that addressed immortal time bias [34] found no association between dementia risk and initiation of metformin, a first-line therapy for type 2 diabetes

Participants receiving retatrutide 12 mg weekly achieved an average weight loss of 24.2% of body weight at 48 weeks the largest weight reduction recorded for any anti-obesity medication to date

NP (with supervisory protocols)

When BCBS covers Zepbound, typical PA requirements include: BMI 30 or 27 with a comorbidity (hypertension, type 2 diabetes, high cholesterol, or OSA), 6 months of documented lifestyle modification (diet and exercise program), and sometimes step therapy requiring trial of other weight loss medications first

As a result, blood sugar levels come down