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Limited human data exists, mostly anecdotal reports and case observations, and no controlled clinical trials have confirmed direct muscle growth or hypertrophy benefits
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If you drink, keep it moderate
reported greater weight loss in obese mice with the GLP-1/GIP/glucagon receptor triagonist compared to GLP-1 receptor agonists, GIP/GLP-1 receptor co-agonists and GLP-1/glucagon receptor agonists including semaglutide and tirzepatide [60]
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(2018, PLOS ONE ): transdermal dihydroberberine (a chemically modified form) applied in a pharmaceutical-grade cream with penetration enhancers achieved roughly 7x higher bioavailability than oral berberine in rats
