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For many people it's B12 depletion and dehydration

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It participates in the metabolism and conversion of homocysteine into methionine which is an amino acid that is essential to liver, kidney, and bladder health

[5] Researchers should be cautious when interpreting effects that appear only at high concentrations, especially if those effects are accompanied by reduced cell viability, stress-response signatures, broad transcriptional disruption, or vehicle-sensitive assay behavior

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