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At the same time, the expected metabolic improvements and weight loss were observed
To test this, we expressed a stable NRF2 mutant in Hs 578T, MDA-MB-231 and MDA-MB-157 cells
Methylation of the CpG islands in the NRF2 gene promoter typically suppresses NRF2 transcriptional activity, leading to reduced expression levels and impacting the cells antioxidant functions [148]
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