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These medications have been FDA-approved for diabetes management and weight loss

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One organelle containing such targets could be mitochondria

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if GI adverse events appear during the dose-escalating phase, HCPs could modify the planned schedule by implementing one or several of the following points: extend the dose-escalation phase duration (24 more weeks with the previous dose or temporary suspension) avoid dose escalation while GI adverse events persist if a GI adverse event is experienced when moving up to a higher dose, go back on the lower one and stay on it for a few days