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Jordan R, et al
Structures of full-length class B receptors were determined in complex with their orthosteric agonist peptides, however, little is known about their extracellular domain (ECD) conformations in the absence of orthosteric ligands, which has limited our understanding of their activation mechanism
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DEXA scan data from the Phase 2 trial showed approximately 26% of total weight lost was lean mass (muscle, water, bone, organs)
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