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A recent review in Fertility and Sterility emphasized how GLP-1s are being considered as part of preconception care for women with PCOS and obesity

This article is based on the core Phase 3 clinical trials of these two oral weight-loss drugsOASIS-1, OASIS-4, and ATTAIN-1and provides a comparative analysis across multiple dimensions, including efficacy ceiling, safety and tolerability, pharmacokinetics, real-world adherence, and future commercial potential

Participants were randomized to placebo or retatrutide at 1 mg, 4 mg (dose-escalation), 4 mg (no escalation), 8 mg (escalation), 8 mg (no escalation), or 12 mg (escalation) for 48 weeks, following a slow titration protocol

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