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The key findings from this clinical program include significant reductions in body weight and fat mass in treatment groups compared to placebo, preferential loss of abdominal and visceral adipose tissue, no changes in serum IGF-1 levels at any dose tested, no negative effects on glucose metabolism or insulin sensitivity, no significant adverse events related to metabolic or endocrine disruption, and safety profile indistinguishable from placebo for most parameters

In C57BL/6J mice treated with OH, both melanin content and the number of melanoma cells were reduced

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When to see a GP See a GP if you think you may have a vitamin B12 or folate deficiency

Evidence from Human Exercise and Biomarker Trials Human studies have added another layer