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Preclinical studies demonstrate that DSIP can alter pain threshold responses, with observed effects that are not reversed by opioid receptor antagonists such as naloxone, suggesting involvement of non-opioid or indirect neuromodulatory pathways [7]
Mobile phase A was 10 mM (NH 4 ) 2 CO 3 and 0.05% NH 4 OH in H 2 O, whereas mobile phase B was 100% acetonitrile
(PubMed) Marko MG, Ahmed T, Bunnell SC, et al
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