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An electrostatic scaffold of salt bridges at the binding interface between GLP-1R and semaglutide analogues In 2021 as mentioned above, a manually designed V-R exchange [43] was introduced into the backbone of semaglutide for an improve GLP-1R ECD affinity

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Accessed11/26/2025, Varrassi G, Rekatsina M, Perrot S, et al

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PPAR inhibition/knockout attenuates GLP-1RA-mediated rescue of insulin secretion in PA-treated NIT-1 cells To further investigate the role of PPAR in the positive effects associated with the GLP-1RA Exe in PA-challenged pancreatic -cells, NIT-1 cells were treated with Ex-4 in conjunction with GSK based on PA exposure