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Indeed, it was recently reported that treatment of cells with H 2 O 2 , which can lower GSH levels, leads to increased expression of NRF2 target genes in a KEAP1-independent mechanism 69

Himani J, Ruban KA (2022) Magnetic and dielectric response of M-type barium hexaferrite

Factors responsible for cellular regeneration depend on high levels of reduced glutathione, yet this antioxidant is easily depleted by toxin exposure, imbalances, and poor nutrition

Furthermore, the concentration of GSH and the GSH/GSSG ratio vary between intracellular organelles, and this compartmentalization is actively regulated in the cell 3

Increased metabotropic glutamate receptor 5 signaling underlies obsessive-compulsive disorder-like behavioral and striatal circuit abnormalities in mice

ATM, a master cell cycle checkpoint kinase, coordinates DNA damage responses throughout the genome