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Following single administration, the elimination half-life of prototype BPC-157 was less than 30 minutes in both species, indicating rapid systemic clearance

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Its defining physicochemical feature is resistance to hydrolysis at low pH, unusual for a peptide of this length and attributed to a proline-rich, conformationally constrained backbone carrying three consecutive prolines plus a fourth at position eight

It is administered by subcutaneous injection

Vomiting Vomiting may be uncommon, but it is one nonetheless

Journal of Orthopaedic Research , 28 (9), 11551161