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This efficient brain penetration is one reason relatively infrequent dosing can maintain neuroplastic effectseach administration delivers substantial compound to target tissues despite rapid plasma clearance.
In CKD patients, even though anemia develops primarily as a result of the decreased lifespan of RBCs caused by the low production of erythropoietin and iron deficiency, eryptosis seems to be a fundamental contributing factor [244,245,246]
& Min, J
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