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Although the mechanisms through which astrocytes maintain BBB integrity are not fully understood, there are several proposed astrocytic-derived soluble factors that may induce vital aspects of the BBB including interleukin-6 (IL-6), glial cell line-derived neurotrophic factor (GDNF), basic fibroblast growth factor (bFGF), fibroblast growth factor 2 (FGF-2), angiopoetin 1 (ANG1), and TGF [45, 46]
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Supplementary material The Supplementary Material for this article can be found online at: References 1 ChenJ.WangM.JoyceA.DeFrancoD.KavosiM.XuX.et al (2014)
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