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Biochemical and omics biomarkers in cognition Classical CSF and plasma biomarkers A40 / A42 (important ratio in amyloid pathology) Total tau / p-tau181 / p-tau217 (tauopathic markers) Neurofilament light (NfL) : axonal degeneration marker GFAP : astrocytic activation BDNF and pro-BDNF : neurotrophic activity IL-6, TNF, IL-1 : neuroinflammation Transcriptomics and epigenomics Hippocampal RNA-seq after chronic administration of Semax or Selank often reveals a neurotrophic activation signature (BDNF, NT3, NGF, NR4A1-3) coupled with anti-inflammatory modulation (NF-B targets down)

This dual action of promoting blood vessel formation and collagen production makes BPC 157 particularly effective in healing processes

Demeule M, Regina A, Che C, Poirier J, Nguyen T, Gabathuler R, et al

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In the Netherlands ambulances, fire departments and emergency rooms have the Cyanokit at their disposal

Human studies remain limited compared to animal research