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This article originally appeared on USA TODAY: The post-weight loss challenge we're not talking about enough Reporting by Sara Moniuszko, USA TODAY / USA TODAY USA TODAY Network via Reuters Connect

the formal RCT is still pending

These are a great idea if youve hit a plateau and are having difficulty losing weight

Targeting the incretins with twincretins The two incretin hormones GIP and GLP-1 co-agonists (twincretins) show similarities and differences

The changes are caused by rapid loss of subcutaneous fat and, to a variable degree, lean muscle mass during sustained caloric restriction not a direct toxic effect of semaglutide itself

Another option, Foundayo, introduces orforglipron, an emerging oral GLP-1 medication that can be consumed anytime without any food or water restrictions