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Diabetologia (2019) 62:1600
10.1128/AAC.02572-12 91 SchaussA
Obtaining it through unregulated online sources significantly increases the risk of receiving counterfeit, contaminated, or incorrectly dosed products
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But biological plausibility does not replace human clinical trial proof
In this context, murine studies have shown that sweet taste receptors (TAS1R2 and TAS1R3) are predominantly expressed in the hypothalamus and brainstem, whereas bitter receptors (TAS2R116, TAS2R118, TAS2R138, TAS2R104) are mainly expressed in the arcuate nucleus, ventromedial hypothalamus, dorsomedial hypothalamus, and nucleus of the solitary tract (120, 121)
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