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7 We offer guidance to help the astute clinician continue this effective antipsychotic by monitoring carefully, treating side effects early, and managing potential drug interactions ( Table 1 )

A clinically meaningful change driven by activation of melanocortin-4 receptors in the hypothalamus

J Biol Chem 281:2234222351 Liu YQ, Jetton TL, Leahy JL (2002) beta-Cell adaptation to insulin resistance

Yes, but there are some important points to remember

Stopping semaglutide doesnt cause a withdrawal syndrome, but you may feel changes as the medication fades out, such as a stronger appetite or a change in digestion

The gastrointestinal tolerability profile is dose-dependent, which is why Wegovy is initiated at a low dose (0.25 mg weekly) and gradually increased over 1620 weeks to the maintenance dose of 2.4 mg weekly