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These secondary indications sometimes face less prior authorization friction than the primary weight-loss indication

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Importantly, autoradiographic analyses in the basal ganglia and cortex of RS patients showed reduced density of -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), N-methyl-D-aspartate (NMDA), and GABA receptors [375]

doi: 10.1152/ajprenal.1982.242.5.F484

In a 68-week clinical trial targeting weight reduction and long-term maintenance in pediatric patients aged 12 years and older with obesity, more patients treated with Wegovy achieved a greater than 5% reduction in baseline BMI compared to those treated with placebo

Summary of included pre-clinical and mechanistic studies regarding the effects of GLP-1-RAs on mental health outcomes)