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[Abstract]2026 Jun 11;15(12):1070

Tirzepatide did not impact metabolic adaptation in people with obesity, but increased fat oxidation

AUA categorizes body of evidence strength as Grade A (well-conducted RCTs or exceptionally strong observational studies), Grade B (RCTs with some weaknesses of procedure or generalizability or generally strong observational studies), or Grade C (observational studies that are inconsistent, have small sample sizes, or have other problems that potentially confound interpretation of data)

Dieting and weight loss regimes, notably those which are rapid or extreme, can also result in nutritional deficits, including B vitamins

A systematic review in 2024 identified 36 studies (35 preclinical, 1 clinical) from 1993 to 2024

W., Murali-Manohar, S., Gong, T., Hui, S