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Ultimately, there is continuous stimulation of the mevalonate pathway, leading to increased cholesterol production and accumulation within tumor cells (68, 70)
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pH profiles indicative of rate-limiting nucleophilic displacement in thioltransferase catalysis
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Fatty acid oxidation is suppressed through downregulation of PPAR and CPT1, resulting in the accumulation of toxic lipid intermediates like ceramides and acylcarnitines
PMID: 21265979
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