Upon administration, gemigliptin binds to DPP-4 and inhibits the breakdown of the incretin hormones, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP)
Pros of GLP-1s: Non-surgical option Can lead to 1520% body weight loss in clinical trials May improve blood sugar, cholesterol, and inflammation Weekly injections, often self-administered Cons of GLP-1s: Real-world weight loss may be lower than clinical trials (510%) Side effects include nausea, vomiting, fatigue, and gastroparesis High cost and limited insurance coverage Weight may return if medication is stopped What is weight loss surgery
Eventually, this results in chronically insufficient GSH levels to neutralize the ROS, leading to oxidative stress that damages lens proteins
& Culpepper, L
The timeline for availability: Lilly will likely price retatrutide at or above Zepbound levels, given the superior efficacy data
HUBERMAN: And it's not something that I've returned to, except every once in a great while, I might do it to augment deep sleep just a little bit