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Across preclinical studies, Epitalon has shown: Telomerase activation and telomere extension: Via TRAP assays and fibroblast lifespan extension beyond the Hayflick limit Epigenetic remodeling: Reversal of chromatin aging, histone modulation, and gene promoter binding Redox homeostasis: Increased antioxidant enzymes (SOD, NQO1, catalase) and reduced ROS, lipid peroxidation, and DNA damage Circadian restoration: Upregulation of AANAT/pCREB, normalized melatonin and cortisol rhythms, and clock gene modulation in humans Cancer risk reduction: Reduced tumor multiplicity and delayed onset in HER-2/neu and colon cancer models

MOXD1 has been implicated in the progression of AMD 40 and anemia 41

Third axis, genome-wide transcriptional modulation

Vitamin B12 has a complex biological activity and takes part in protein synthesis particularly in neuronal and hepatic tissues

No drug interactions are currently known

Administered via subcutaneous injection or oral capsule (for GI-specific applications)