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Furthermore, the administration of denatonium benzoate, in conjunction with gavage of glucose, causes the secretion of GLP-1 and subsequently elevates plasma insulin levels and reduces plasma glucose in db/db mice [195]

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GLP-1 originating from the gut has a very short circulating half-life of only 12 min due to its rapid inactivation by the enzyme dipeptidylpeptidase-4 (DPP-4) and subsequent clearance through the kidneys