Here is a more specific review of those issues
B12 injection shots can usually be felt within 24 hours (and a change should show in blood tests after a month or two) A high dose of B12 oral supplementation takes the same time as an injection: roughly 24 hours to feel an improvement and then up to 2 months to show in blood markers
Realistic expectations: Successful candidates understand that AOD-9604 is an adjunct to comprehensive lifestyle modification, not a standalone solution
It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile
The severity and duration of deficiency are primary determinantspatients with mild, recently developed deficiency typically respond more rapidly than those with longstanding, severe depletion
This guide explains why B12 levels drop, the symptoms to look out for, and how B12 injections can help restore energy and wellbeing