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( 5.10 ) 5.1Risk of Thyroid C-Cell Tumors In both sexes of rats, tirzepatide caused a dose-dependent and treatment-duration-dependent increase in the incidence of thyroid C-cell tumors (adenomas and carcinomas) in a 2-year study at clinically relevant plasma exposures [see Nonclinical Toxicology ( 13.1 )]

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is supported by the Alzheimers Drug Discovery Foundation (GC-201908-2019443), Cure Alzheimers Fund, Hevolution/American Federation for Aging Research, National Institute on Aging (R01AG068293, R01AG065839, U54AG079754, R24AG073199), National Institute of Neurological Disorders and Stroke (R21NS125171), Rainwater Charitable Foundation and US Department of Veterans Affairs (I01BX005717)

Typical Results Timeline: 23 weeks: Subtle glow improvement 46 weeks: Visible brightness 23 months: Reduction in pigmentation Collagen, on the other hand, improves skin hydration and smoothness but does not significantly lighten dark spots

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