GLP-1 (glucagon-like peptide-1) medications were originally developed to treat type 2 diabetes, but theyve made headlines for their ability to support weight loss even in people without diabetes
Tracking food intake can be beneficial in identifying specific triggers
Importantly, functional B12 deficiency can sometimes coexist with high total B12 levels, especially in kidney disease, and may require additional testing with methylmalonic acid (MMA) or holotranscobalamin if deficiency is suspected clinically
Jun 23, 2025 Learn more about the inspiring story of Cigna Healthcare customer Bobby Neeb
When CYP1A2 (Phase I) oxidizes an aromatic amine to its N-hydroxy derivative, and then O-acetyltransferase activity (catalyzed by the same NAT enzymes) transfers an acetyl group to the oxygen, it creates a highly reactive N-acetoxyarylamine that binds DNA
These additions can reduce some side effects but they do not replace the need for electrolyte supplementation