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Dehydration may cause kidney failure, which can lead to the need for dialysis

Common side effects: Nausea, vomiting, constipation or diarrhoea: usually worst when starting and after each dose increase, and usually improves with time

Research suggests it can enhance fibroblast activity, promote vascularization, and increase the expression of genes involved in tissue growth and remodeling

Once maintenance doses were reached, gastrointestinal symptoms typically stabilized at more manageable levels

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The pregnancy rate was also increased