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Institutional protocols recommend initiation in the operating room or ICU with cardiac telemetry
In the lungs, after entering in type II alveolar cells, SARS-CoV-2 infected cells become defective for surfactant production (Ghati et al., 2021) and release cytokines, like IL-8 among others, which in turn activate alveolar macrophages to release IL-1, IL-6, and TNF-, that induce natural killer and dendritic cell differentiation and macrophage M1 polarization, enhancing the proinflammatory response with increased vasodilation causing neutrophil and activated T cell influx from the capillaries into the alveolus, all leading to the cytokine storm (Carcaterra and Caruso, 2021
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However, it is essential to seek medical advice before using NAC for health enhancement
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Upon completion of chain assembly, side-chain protecting groups were cleaved using trifluoroacetic acid (TFA), water, and triisopropylsilane (Sigma-Aldrich, Darmstadt, Germany)
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