Transcriptomic analysis and pathway validation To further elucidate the mechanism of EGCG-Zn, we performed transcriptome sequencing on rectal tissues from control (Control), irradiated (RT), and EGCG-Zn-treated mice
2.2.2 Type II cells Although they are a relatively small subpopulation (only about 19-25% of all TRCs), they might be considered as the key receptor cells
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When SAM is reduced from MTHFR-impaired methionine regeneration, EZH2 and other histone methyltransferases lose substrate availability producing progressive loss of repressive histone methylation marks at senescence-promoting gene promoters
Additionally, it enhances energy expenditure and improves lipid metabolism, contributing to better overall metabolic health