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Data availability The datasets generated and analyzed during this study are included in the Supplementary files

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Periodic boundary conditions were used with a cutoff of 10 for non-bonded interactions and the Particle Mesh Ewald method for long-range electrostatics

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Yang C, Xue Y, Duan Y et al (2024) Extracellular vesicles and their engineering strategies, delivery systems, and biomedical applications

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At the molecular level, AOD-9604 interacts with beta-3 adrenergic receptors on adipocytes (fat cells), triggering a signaling cascade that increases intracellular cyclic AMP levels

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