Ferritin upregulation inhibits estradiol synthesis via the NF-B/iNOS pathway and downregulates the Nrf2/GPX4 pathway, exacerbating ovarian damage (Sze et al., 2022)
doi: 10.1056/NEJMoa2107519 113 EhsesJACasillaVRDotyTPospisilikJAWinterKDDemuthHUet al
14 Diabetes is an endocrine disease characterized by abnormally high blood glucose levels
Greater understanding of trial generalizability is needed. In the cross-sectional study, the researchers examined a cohort of 8,767 participants aged 20 years or older from the National Health and Nutrition Examination Survey to determine proportions of those who were met the FDAs label criteria for weight loss treatment and those who met trial exclusion criteria
Thus, abnormal estrogen metabolism, which results in increased E2 levels, may contribute to a higher occurrence of GD
As it was a Korea-customized clinical trial, the company set the obesity standard to suit the domestic guideline of BMI 25kg/