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The BMJ paper did not prove these medications fail. It documented what chronic disease looks like when therapy is withdrawn

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What are the initiation criteria for GLP-1 and GIP therapy

However, the benefits expected of an improved stability molecule with a lower potency need to be carefully weighted against other considerations such as manufacturing and formulation requirements as well as patient convenience and compliance

This early conditioning can contribute to long-term unhealthy eating habits, increasing the risk of obesity and related metabolic dysfunction