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Generally yes, but some antidepressants may reduce weight loss

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Biochimica et Biophysica Acta (BBA) - General Subjects , 1830(5), 32893303

Research dose/evidence: Some cosmetic studies show Acmella extract (the source of spilanthol) improves wrinkle appearance, but there are fewer large clinical trials than for retinoids or peptides (there never are with botanical extracts)

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