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The peptide exhibits consistent efficacy in models of acute and chronic injury regardless of administration route (intraperitoneal, oral, or local application), a unique characteristic distinguishing it from other growth factors that typically require localized delivery with carrier systems

Restoration of altered endogenous neurosteroid levels via modulation of steroidogenesis mediated by pregnane xenobiotic receptors (PXR) and the endocannabinoid system has been suggested as an alternative to direct administration of neurosteroids (89, 178, 337)

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10.1002/adma.201900730 22 HallS.RudrawarS.ZunkM.BernaitisN.AroraD.McDermottC.et al (2016)