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The net result, in the liver, is transcriptional repression of the CYP7A1 gene, which encodes the rate-limiting enzyme in the classic pathway of bile acid synthesis

References : [1] Mun Y, Kim W, Shin D

doi: 10.1016/j.bbacli.2016.05.006 26 SaundersJ

When we don't get enough vitamin B6, it can lead to: Higher homocysteine levels, which are a known risk factor for atherosclerotic cardiovascular disease, have been associated with insulin resistance and Type 2 diabetes

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Its ability to scavenge reactive oxygen species (ROS) is especially critical given the CNSs high metabolic activity and inherent susceptibility to oxidative stress-induced cellular injury