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Gut microbiota can modulate GLP-1 secretion by influencing L-cell activity through metabolic products, primarily SCFAs, which activate FFAR2/3 receptors

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However, it is important to note that this study was very small and only looked at a sample of 11 people

These subjective experiences suggest the medications may influence the psychological and neurological drivers of eating beyond simple physiological hunger, though systematic studies confirming these effects are limited

Since then, there have been many articles and findings underscoring this point: fatigue can linger on even after a person normalizes their thyroid hormone levels