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Excessive Alcohol: Alcohol can irritate the stomach lining and increase the risk of low blood sugar

This can lead to a reduction in overall body fat, which can contribute to weight loss

Knockdown of preproglucagon expression in the hindbrain as well as central GLP-1R antagonism results in hyperphagia and body weight gain in rats indicating that these neurons are essential for maintenance of normal body weight (Barrera et al., 1996)