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It directly donates a reducing equivalent (a hydrogen electron) to these unstable molecules, neutralizing them into harmless water and oxygen before they can wreak havoc on the cell's delicate machinery

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Jul 7 2025;46(26):2564-2575

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383 SIRT5-catalyzed demalonylation and inactivation of SDHA block the TCA cycle and induce succinate accumulation, promoting tumorigenesis and drug resistance