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As described above for PABA/NO, JS-K, and GSNO, the NHGs, in accordance with GT expression patterns, contribute to chemotherapy by producing locally high levels of NO which can rapidly react with O 2 - to generate the potent oxidant peroxynitrite that, in turn causes extensive cellular damage, including the nitration of protein tyrosine residues (Kirsch et al., 2001)
10.1074/jbc.M308035200 37 FujiwaraS.KawazoeT.OhnishiK.KitagawaT.PopaC.VallsM.et al (2016)
Sample analyses were further conducted using a LC-MS/MS-8050 (Shimadzu Scientific, Inc., Columbia, MD, USA) Triple Quad mass spectrometer (QqQ) equipped with a UHPLC NexeraX2 system
Meanwhile, Sph_12-38 has no significant cytotoxicity to human keratinocytes (HKs) at its high concentration (33.5 M)
Calcium channel blockers are a good example
