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Glucagon-like peptide-1 receptor agonists (GLP-1RAs), along with glucose-dependent insulinotropic polypeptide (GIP) and glucagon (GCG) dual or triple receptor agonists that modulate multiple metabolic pathways, have attracted significant scientific interest due to their multifaceted roles in metabolic regulation

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But the annual cost of these drugs in the US upwards of $11,000 at recent list prices, though net prices may be lower with rebates negotiated by pharmacy benefit managers has raised concerns about the fiscal impact of broad coverage of GLP-1 drugs on Medicare, other health insurers, and patients

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Developments within the Market and Industry: Covers notable events like the expansion of the pipeline for oral GLP-1, license agreements by big pharmaceuticals, developments in clinical studies, payer attention, the reimbursement situation, the role of telemedicine in prescribing and increasing preference for non-injectable options

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