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3.3.1.3 Targeting interleukins Tocilizumab, an IL-6 receptor inhibitor, showed a significantly higher myocardial salvage index but no significant difference in final infarct volume compared to placebo ( Anakinra, an IL-1 receptor antagonist, demonstrated a significant reduction in 1-year death or new-onset heart failure in STEMI patients ( Canakinumab, an interleukin-1 inhibitor, in patients with prior MI and elevated CRP, provided strong evidence for a significant reduction in the risk of recurrent MI, stroke, and cardiovascular death (Ridker et al., 2017)