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TLS in the kidney are associated with aggravated histologic inflammation and impaired kidney function, representing novel therapeutic targets in kidney diseases

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Key considerations for B12 intravenous dosing include: Initial dose: 1,000 mcg per infusion Frequency of administration: varies based on clinical need Monitoring of patient response to adjust dosing as necessary IV Infusion Methods and Duration B12 IV infusions are given slowly to avoid side effects

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Our work suggests that GIPR antagonism does not require the central production of GLP-1, as ablation of the Ppg neuron population had little effect on the weight loss outcomes