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The medication is injected subcutaneously into the abdomen, thigh, or upper arm, with rotation of injection sites recommended
SURPASS-2 showed tirzepatide was superior to semaglutide 1mg for both A1C reduction (2.09% vs 1.86%) and weight loss (12.4% vs 6.2%) at the 15mg dose, establishing the clinical relevance of dual-agonism over selective GLP-1 agonism
Brinkman, J
The cardio
As a ghrelin receptor agonist, it can simulate the secretion of ghrelin from the gastrointestinal tract, increasing patients' appetite and weight
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